Human aging is the root of many problems. Scientific research experts have been conducting research on anti-aging and anti-aging non-stop! As the years have accumulated, the research results have become clearer. Experts are committed to clarifying the principles behind it and making all possibilities possible from a scientific perspective, so that in this generation, reverse aging is no longer a fantasy!
Today, let us use an article to quickly learn about a Harvard professor who has made proud achievements in anti-aging research, and use his daily supplement list to make strong preparations for reverse aging as early as possible.
Key figure in anti-aging research
David Sinclair, who has attracted much attention in recent years, is a tenured professor at Harvard Medical School who has made significant contributions to anti-aging research. He is also the director of the Paul F. Glenn Center for Biology of Aging Research.
David Sinclair, 54, began his research career in Australia when he studied at the University of New South Wales in Sydney and obtained a Bachelor of Science (first class honors). After receiving his PhD in molecular genetics in 1995, he went to the Massachusetts Institute of Technology to work as a researcher with Leonard P. Guarente, and in 1999 became a tenured professor at Harvard Medical School.
In 2013, David Sinclair and his team discovered that by applying β-NMN (nicotinamide mononucleotide), not only can the molecules in the cells be effectively repaired, but the connection between the mitochondria and the nucleus can be stimulated, thereby restoring the Noga factor to youth. Since then, he has devoted himself to anti-aging research since his achievements that made him famous.
David Sinclair’s Nutritional Supplement List
Morning supplement list:
|
β-Nicotinamide mononucleotide (NMN) |
1 g per day |
|
Resveratrol |
1 g per day |
|
Fisetin |
500 mg per day |
|
Quercetin |
500 mg per day |
|
Spermidine |
1 g per day |
Evening supplement list:
|
Metformin |
Prescription, 800 mg daily, except before exercise |
Other additional supplements:
|
Vitamin D3 |
|
Vitamin K2 |
|
Omega-3 Fish Oil |
|
Alpha Lipoic Acid |
|
Coenzyme Q10 |
|
Aspirin: 81 mg daily |
|
Statins: prescription cholesterol-lowering drugs |
Today we are going to discuss the most powerful supplements that are the key to anti-aging in David Sinclair’s supplement list. Among them, the most noteworthy ones are: NMN, resveratrol, fisetin and quercetin!
The key codes for maintaining health and longevity—NAD+, mitochondria, Sirtuins
Before that, we must first understand the three key codes: NAD+, mitochondria, and Sirtuins. These are key elements that affect human health and longevity. They can also more effectively explain how NMN can achieve human longevity and health. reason.
A research report published by Professor David Sinclair in 2013 pointed out that the NAD+ (Nicotinamide Adenine Dinucleotide, referred to as "Coenzyme I") substance in the human body can resist aging, reverse aging, accelerate fat metabolism, and improve sleep quality. to prevent various diseases. NAD+ in the human body will decline rapidly with age, but the human body itself cannot produce NAD+ substances! NAD+ can only be replenished through external NMN or NR, and it is the key to stimulating Sirtuins and mitochondria to have significant effects! NAD+ is also the central processing unit of our body. Losing NAD+ for 30 seconds has a significant impact on human health.
Mitochondria, on the other hand, have the function of promoting cell activities. They can not only produce the energy needed by the body, but also affect the metabolism of the body and the operation of the nervous system. The last item is Sirtuin (deacetylase), which can control the number and activity of mitochondria in the human body. It can also activate human's own DNA to repair cells. It is an important element for humans to maintain health and longevity.
The efficacy of NMN
NMN (β-nicotinamide mononucleotide) is one of the derivatives of vitamin B3 (nicotinic acid) and an intermediate product of NAD+ biosynthesis. It is composed of a phosphate group and contains ribose and nicotinamide. ) biologically active nucleotides formed by nucleoside reactions.
The operating principles and mechanisms of NMN are actually very simple but effective. Ingesting NMN can be converted into NAD+, which can then activate Sirtuins1~7 longevity genes and activate mitochondria to make the human body healthy, youthful and longevity, while repairing cellular DNA. Helps stem cell activation to maintain telomere length. When the above functions are operating, the body's immune regulation will increase, achieving the preventive effect of reducing infertility, preventing chronic diseases, and making people healthier, longer and younger!
NMN exists in small amounts in various natural foods, such as vegetables such as cauliflower and broccoli, which contain 0.25 to 1.12 and 0 to 0.90 mg of NMN per 100 grams, and fruit avocados and tomatoes containing 0.36 to 0.36 mg per 100 grams. 1.60 and 0.26 to 0.30 mg of NMN, while meat such as beef contains 0.06 to 0.42 mg of NMN per 100 grams.
One of the manufacturing methods of NMN supplements is simply to extract NMN elements from natural foods, so that people can absorb higher purity NMN faster by taking NMN supplements.
Recommended daily dose of NMN
According to current clinical studies, NMN is safe in doses ranging from 100 mg to 2,000 mg per day. Here are the recommended daily doses of NMN for different people:
|
Weighing less than 90 kg |
Weighing more than 90 kg |
|
|
Under 45 years old |
250 mg |
500 mg |
|
45 to 60 years old |
500 mg |
750mg |
|
Over 60 years old |
750mg |
1000mg |
Resveratrol Benefits of Resveratrol
Resveratrol is an activator that starts the operation of sirtuins (deacetylase). It is often said that wine is good for health precisely because of the presence of resveratrol in it. The concentration of resveratrol in red wine can be as high as 100 mmol/L, while the concentration of resveratrol in white wine is relatively low.
Resveratrol and its derivatives are mainly found in a variety of plants, such as the skins of commonly seen grapes, blueberries, raspberries, mulberries and peanuts. Simply put, resveratrol is like the patron saint of plants, able to protect plants from external damage such as bacteria or fungi, ultraviolet rays, radiation, etc., and has super antioxidant capabilities. Research also points out that resveratrol can effectively reduce inflammation and has multiple health effects, such as slowing down oxidation, improving obesity, improving memory, improving metabolism, helping cardiovascular health, etc. If you take resveratrol through natural food, the effect will be limited and not obvious based on the food portion ratio. It will be more convenient and effective to choose a concentrated resveratrol supplement extracted from the food.
In addition, there are two things to note when we buy resveratrol. The first is that what we buy must be trans-Resveratrol (Trans-Resveratrol), because according to the research of Professor David Sinclair, cis-Resveratrol Veratrol does not activate Sirtuin (desacetylase). Secondly, the purity of trans-resveratrol is very important and must be above 98%. Professor David Sinclair also pointed out that taking resveratrol with a purity of less than 50% will cause diarrhea, so please be careful.
Resveratrol Recommended Daily Dosage of Resveratrol
To effectively improve body function, the recommended daily intake of resveratrol is 500 to 1,000 mg. It should also be noted that due to the nearly water-insoluble nature of resveratrol, resveratrol needs to be taken with dietary fat (such as cheese) for optimal absorption. Therefore, it is recommended to take resveratrol after a meal. Supplements.
The efficacy of Fisetin fisetin
Fisetin Fisetin (also known as fisetin, fisetin, fisetin) is a plant-derived flavonol found only in small amounts in fruits and vegetables. Studies have shown that fisetin can help improve the acuity of memory and cognitive functions. At the same time, scientific researchers are also actively studying the potential effect of fisetin on removing senescent cells accumulated during the aging process. The effects of long-term use include: antioxidant, delaying aging, improving body function, improving memory, protecting the brain, improving brain cognition, maintaining healthy neurological function, removing old cells, stimulating and helping brain circuits related to long-term memory function and brain signaling pathways.
Recommended Daily Dosage of Fisetin Fisetin
The recommended daily dose of fisetin is 100 mg, allowing healthy cells to flourish or replace old cells. According to current research, it should be noted that no more than 300 mg of fisetin should be taken per day. Among natural foods, the content of fisetin found in strawberries is particularly high, followed closely by apples. The content of fisetin in strawberries is about five times that of apples. At the same time, the content is generally found in mangoes, kiwis, grapes, Thirty times more than tomatoes, onions, cucumbers and various nuts. However, the fisetin content in these foods is still not comparable to the fisetin content found in supplements.
Quercetin benefits
Quercetin is a well-researched bioflavonoid found naturally in fruits and vegetables. As a potent antioxidant, quercetin is thought to help maintain healthy cholesterol levels and maintain a healthy immune system. Particular attention has been paid to its role in strengthening the body's resistance to the respiratory tract and enhancing the anti-viral effects of zinc.
Quercetin is also known as "natural anti-histamine", which helps inhibit the histamine released by immune cells in the body, thereby relieving the symptoms of sensitivity and inflammation in the body, promoting cell repair, and helping cells protect themselves from damage. or infection. Long-term use of Quercetin can help resist oxidation, delay aging, improve body functions, control cholesterol, enhance the immune system, reduce the body's inflammatory response, and help suppress allergic reactions.
Quercetin Recommended Daily Dosage of Quercetin
The recommended daily dose of quercetin is 1,000 to 2,000 mg. Since bromelain helps increase the absorption level of quercetin, consumers can choose quercetin supplements on the market that contain bromelain to make the effect more significant. Since quercetin is also a fat-soluble substance, it is recommended to take it with food for optimal absorption.
Tailor-made supplement list for yourself to make strong preparations for anti-aging as early as possible
The complete interpretation of the phrase "eat well" should be: I hope you will be full and eat well. In addition to feeling the deliciousness of the food, I also hope that the nutrients in it will bring you health.
Modern people are busy with life and work. Regardless of eating habits, just having three meals on time is a relief. However, it is even more challenging to have adequate and balanced nutrition. Whether there are too many temptations of various delicacies and sweets from the outside world, or you need to use different ingredients to make various dishes to satisfy your appetite, you must be familiar with the nutrients and portions of various foods so that you can consume sufficient and accurate amounts in your daily diet. Nutrients are so difficult!
It is indeed a difficult task to spend a certain amount of effort every day to accurately measure and calculate what ingredients are needed for each meal in order to absorb enough nutrients that your body needs, especially for busy people who do not eat regularly. In a busy life It is even more difficult to take into account regular eating and a balanced diet at the same time. However, supplementing the nutrients required by the body is indeed a daily requirement. If you are also a person with a busy and compact life, or you have higher quality requirements for your own health, nutritional supplements are concentrated extracts that can effectively supplement the daily nutritional needs of the human body. It allows everyone to make a customized supplement list based on their own body needs, which is absolutely ideal.
In addition, many people overlook the fact that various anti-aging nutrients require a certain dose to achieve the best effect. Supplements can accurately provide individual nutrients. You only need to choose according to your needs and take them regularly. Easily ensure your body is getting enough of the nutrients it needs every day! With the advancement of the current era of scientific research, unlike nutritional supplements with single functions in the past, today's supplements are supported by more reliable research data. While their functions are becoming more comprehensive, their effects are also more significant. Therefore, starting from today, you should also seize the time to create an exclusive anti-aging supplement list for yourself, so that in the future you can thank yourself for your foresight!