"Three major questions about the NMN craze, are you following the market with the brigade?" 》
In 2014, Dr. David Sinclair of Harvard Medical School made astonishing statements at the TED Forum, such as "Age can be reversed" and "Aging is a disease." He also stated that most people can start to slow down or even reverse aging. The method is quite simple: moderate amounts. Exercise and fasting, as well as taking a common diabetes drug Metformin (Metformin) on the market, plus two supplements NMN (Nicotinamide Mononucleotide) and Resveratrol (Resveratrol) can bring about quite significant results. Effect.
Related products were popping up all over the place right away, and the promotional words made it seem like you'd be eighteen or twenty-two after eating them. The simplest and most direct question is: does it work or not? Are you from Mieh?
There are many voices questioning Sinclair on the Internet. It is actually a very good phenomenon to have doubts. There are several main types of doubts:
[(Question 1) Intermittent fasting actually has no benefits, it is unnecessary and even harmful]
David Sinclair said that research has found that when the human body faces major difficulties, such as fatigue, famine, etc., it will cause the body to enter "repair mode" to repair the wear and tear of DNA due to age, that is, to restore parts of the body to a younger state. state.
Will it be restored to the point of rejuvenation? According to Dr. Morgan Levine, a professor at Yale University who also conducts aging research, human aging is due to the loss of information during the body's cell replication process, resulting in a pile of substandard "zombie cells" that will not eliminate themselves ( senescence cells), occupying a certain position and blocking the rotation of the earth, causing various symptoms of aging in the body. Before there is a way to specifically eliminate these cells, what everyone can do is to control physiological age, that is, to maintain the health of various body functions.
Does fasting have any effect on the body? Canadian national treasure mixed martial arts champion George Saint-Pierre once forcibly gained weight and accidentally contracted ulcerative colitis. Doctors said there was no cure and he might need to end his career as a fighter and take long-term medication. Georges St. Pierre took it upon himself to undergo a very extreme "water fast". He fasted completely for five consecutive days every week. During this period, he only drank water and replenished the minerals lost during special training. As a result, he successfully overcame the disease and never relapsed. Saint-Pierre is a professional athlete who pays great attention to health and strives to keep his body in top operating condition at all times. His methods may not be accessible to everyone, but is fasting useful? We can learn a lot from him.
[(Question 2) NMN and other supplements lack scientific research data support, and many people say they have no special effects]
The current main NMN data mainly comes from white mouse experiments, and human clinical trials are quite recent. David Sinclair said that supplements such as NMN are very safe and meet FDA certification, but he also emphasized that anti-aging programs must constantly monitor the body's response. Celebrities and scientists who support anti-aging health products, such as Professor Dr. Andrew Huberman, themselves undergo regular physical examinations, monitor various data and then adjust their living habits. Enthusiastic NMN supporters in North America also have similar practices, and some even regularly share their progress online.
Can NMN and NR series of microphones restore body functions to a younger level? Some experiments have confirmed that the effect is significant. Bryan Johnson, an innovation and technology entrepreneur, spent millions on the "Blueprint" project a few years ago. In the past two years, he has used various latest medical research to maintain his body in Top status. He experimented with taking NMN and NR for three months, and the results showed that the NAD level in his body (an important indicator of comprehensive body function) was close to that of a 16-year-old young man, and he himself is 47 years old.
Family viewers must not just imitate Bayern Johnson's blueprint plan. He has a professional medical team monitoring various body parameters 24 hours a day, and his daily living habits are also very extreme, such as taking at least dozens of different foods a day. Supplements, specially designed physical training, no smoking, no drinking, almost complete abstinence from sugar (you can eat a little black chocolate and a spoonful of honey when you indulge), this kind of life is not something that ordinary people like us can cope with. He also explained that the blueprint experiment hopes to show how far the top anti-aging technology can push the body, and popularization is not his consideration. But are NMN and its sister product NR effective? The answer is quite obvious.
[(Question 3) Is David Sinclair trustworthy? 】
The most notorious thing about Dr. Sinclair is that his company applied to list NMN as a prescription drug, prohibiting general market sales. When Hong Kong users go to Amazon, they will find that the brand they are taking may have been removed from the shelves and cannot be purchased. Critics who questioned him even pointed out that he also praised the efficacy of Resveratrol before, and then applied for an injunction in an attempt to exclusively possess the patent. He himself published an open letter at the end of last year, stating that he was not involved in the company's daily operations or business decisions, but criticisms accusing him of greed have not stopped.
Combining the research results published by other scientists (such as Yamanaka factors) and experiments like the Blueprint Project, the theory of anti-aging or reverse aging has a considerable practical basis, and the general direction is also obvious. Sinclair may be just an ivory tower scholar who has no business making decisions. He may also be a money-minded businessman, but this does not affect the development direction or credibility of the entire anti-aging scientific research. Biological age is malleable. The consensus of many scientists.
Mr. Lu from Regentify in Hong Kong said that reversing age is a long-term lifestyle plan, and it cannot be "done" by taking two pills, nor can one read a book to read about old age. Dr. Morgan Levine invented the "physiological age" calculation formula and made it free and open to the public. You can input physical examination data such as creatinine, white blood cell index, etc. online to calculate your true biological age. Everyone has different physiological conditions and needs. For example, some people need Pqq to assist brain maintenance in addition to NMN/Resveratrol, some people respond better to NR, etc... The key point is that one method needs to be adjusted after work. Press and hold the data reflected by the body to refer to the correction. Regentify is committed to collecting various nutritional supplements based on longevity scientific research, hoping to bring the most affordable and comprehensive tools to help you find your own health span.